“Hacking the software of life”
– Dr Tal Zaks, Moderna’s Chief Medical Officer.
1. What is mRNA?
m – messenger / RNA – RiboNucleic Acid.
Firstly, it must be said that an RNA vaccine isn’t a vaccine at all. It doesn’t illicit an immune response. It has to be turned into a protein, and it’s the protein in turn, that creates the immune response. A messenger RNA vaccine is actually genetic engineering. You’ll have cells in your body that will produce protein to which your body will amount an immune response. That’s called an auto-immune disease. The potential for this to go horribly wrong is enormous.
Here’s the idea behind mRNA: Instead of producing protein drugs using genetically engineered bacteria in dedicated manufacturing plants—the dominant biotech model of the past 30 years—why not enable the human body to produce its own protein drugs, on demand?
Researchers began tinkering in the mid-1990s with nucleic acid vaccines, which include DNA vaccines and messenger RNA (mRNA) vaccines. As a form of gene therapy, both represent a significant departure from classical vaccines, in which typically introduce a vaccine antigen to produce an immune response, nucleic acid vaccines instead send the body instructions to produce the antigen itself.
In the mRNA is a chemical messenger that contains instructions for making protein’s or ‘code’. This code is injected into the body, and instructs the machinery in your cells to produce particular proteins. Your body then becomes a ‘vaccine factory’, producing parts of the virus that trigger the immune system.
Although it may sound simple to use mRNA to express proteins into cells, there are several obstacles in practical applications. For example, cells sense the invasion of foreign mRNA and activate the body’s innate immune system to degrade these foreign nucleic acids. This is the body’s mechanism for self-protection to prevent cells from being manipulated by intruders.
Messenger RNA is a technique that was abandoned by several large pharmaceutical and biotech companies over the years, as they were unable to overcome the dangerous side-effects of getting RNA into cells.
As of recently, no mRNA drug had been approved for human use, other than rival mRNA vaccine researcher Moderna’s government fast-tracked vaccine; mRNA-1273 in mid-March.
Then recently, almost out of the blue, Pfizer, in conjunction with the German-based BioNTech Group, announced their vaccine, BNT162b2, was showing a 90% efficacy rate.
The BioNtech founders; Ozlem Tureci and Ugur Sahin [click it], a German-Turkish couple, are behind the vaccine. It may bolster their fortune to more than $3.8 billion.
Some feel the timing of Pfizer’s announcement was political, and it was delayed until, or timed to coincide, with a certain recent ‘expected’ outcome.
In order to protect mRNA molecules from the body’s natural defenses, drug developers must wrap them in a protective casing. In the earlier days of research on mRNA, biotech company Moderna, also producing an mRNA vaccine, that meant putting its Crigler-Najjar therapy in nanoparticles made of lipids. But dose too little, and you don’t get enough enzyme to affect the disease; dose too much, and the drug is too toxic for patients. Nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years.
The idea of using mRNA to ask the human body to read the instructions and manufacture the viral proteins is not new. Researchers almost two decades ago demonstrated that externally supplied mRNA is translated into the encoded protein. However, mRNA is not a very stable molecule, which prevented those mRNA vaccines from becoming a reality.
Also, if gene therapy ‘chooses’ certain types of viruses as vectors, it can actually cause fatal side effects, or induce patients to develop leukemia.
mRNA itself is also very unstable and difficult to develop into drugs. A few years after it’s inception, scientists discovered that the mRNA synthesized in the lab could trigger an immune response after injection, resulting in a more dangerous inflammatory response, than the disease being treated.
Several workarounds for this issue have been proposed, including vaccines where the genetic material (RNA or DNA) “self-amplifies.” However, the workaround of choice to this lack of immune response and other obstacles for DNA/RNA vaccines is the incorporation of nanotechnology into these vaccines. As a result, the use of nanoparticles as the carriers for the genetic material in these vaccines has been widely promoted and studied, as well as touted as the best way to improve their stability, increase their targeted delivery ability and enhance the immune response they provoke.
Since at least last year, the smaller pharma company included in ‘operation warp-speed’, Moderna, has sought to resolve this issue by adding “nano-particles” to its mRNA vaccine, a modification financed by the Defense Advanced Research Projects Agency (DARPA).
Pfizer’s coronavirus vaccine relies on a new, unproven technology. This diagram shows how it differs from other candidates;
And what Machiavellian medical matrix would be complete without the Defense Advanced Research Projects Agency (DARPA)? It’s important to note that DARPA has been very interested in healthcare, specifically mRNA vaccines, since 2010. It was also around the same time that the Bill and Melinda Gates Foundation also began heavily funding DNA and RNA vaccine research.
DARPA often frames the controversial technologies it develops as being developed to mainly advance medicine and healthcare, whereas evidence suggests otherwise. DARPA has a long history in bringing nightmares into reality; another long-standing DARPA program, is known as “Living Foundries.” According to DARPA’s website, Living Foundries;
“…aims to enable adaptable, scalable, and on-demand production of such molecules by programming the fundamental metabolic processes of biological systems to generate a vast number of complex molecules that are not otherwise accessible. Through Living Foundries, DARPA is transforming synthetic biomanufacturing into a predictable engineering practice supportive of a broad range of national security objectives.darpa – Defense Advanced Research Projects Agency
When the genomic sequence of the 2019 coronavirus was first uploaded by Chinese scientists on January 11 to GISAID, the global influenza strain public database, the Moderna team had a vaccine design ready within 48 hours.
It shipped a batch of its first vaccine candidate to the National Institutes of Health (NIH) for a phase one study just 42 days after that. On March 16th, Moderna’s mRNA vaccine, which consists of an entirely untested gene editing technology to initiate immunity to disease, was injected into humans for the first time. [Moderna’s PDF report]
That’s lightning fast. Vaccines typically take years (or in some cases, decades) to develop, but it’s not fast enough for Moderna CEO Stéphane Bancel. “Every day we’re losing lives; we really believe that every day matters,” he said.
Bancel became a Billionaire through the sale of Moderna stock that jumped 30%+ on Moderna’s dubious phase I trial results. If you’re wondering how they get away with clear insider-trading, and biotech is rife with it, its done via prearranged 10b5-1 trading plans. They work best with a ‘crystal ball’.
Fauci is also moving forward, without waiting for the green light from trials or the US Government. In an appearance on NBC’s Today Show, Fauci was asked whether he thought it was “in the realm of possibility” to have a potential vaccine ready for wide distribution by January;
“In other words, you don’t wait until you get an answer before you start manufacturing. You at risk — proactively — start making it, assuming it’s going to work,” Fauci said. “And if it does, then you can scale up and hopefully get to that timeline.”Anthony Fauci, NPR
The following day after Pfizer announced their 90% efficacy rate, Dr. Anthony Fauci said Pfizer’s success was ‘extraordinary’, and shots will likely be available for most Americans who want it by April.
The Pfizer plant in Michigan is now the leading edge of the crash program to inoculate America. It’s vaccine stored in 350 ultra-cold freezers waiting for FDA approval. Army General Gus Perna, in charge of delivering the vaccine, has been counting on Pfizer to be the first and the most difficult to distribute because it requires two shots; since the body breaks down mRNA quickly, these vaccines require a booster shot. Pfizer’s vaccine must be stored and transported at minus 70C (-158F), in special suitcases, making administering a dose not possible at your local doctor.
Any vaccine that needs to be shipped and stored at -70 isn’t a vaccine. It’s a transfection agent, kept alive so it can infect your cells and transfer genetic material. This is genetic manipulation on a global scale.
“Some of the vaccine candidates under development, specifically the RNA vaccine candidates, require a very challenging cold chain, any break of the cold chain can considerably reduce vaccine potency.”Rongjun Chen – biomaterials engineering at Imperial College London
After being transported and held in storage the Pfizer vaccine can last for only about 24 hours at “normal” refrigerated temperatures, Dr Chen said.
Pfizer is delivering two shots three weeks apart, while participants in Moderna’s trial are receiving two shots 28 days apart.
Moderna and Pfizer’s phase-three trials were neck-and-neck until Pfizer announced its promising results on Monday, 9/Nov. Pfizer is still waiting on more safety data, however — and the trial results still need to be evaluated by the US Food and Drug Administration. Moderna also expects to release findings this month. MRNA:NASDAQ may be a buy at $76 at the time of writing [11/Nov].
Speaking of pump and dumps; on 9/Nov Pfizer CEO Albert Bourla sold 62% of his stock, valued at $5.6 million, on the same day the company recently announced its experimental COVID-19 vaccine succeeded in clinical trials. The announcement sent Pfizer’s shares soaring almost 15% on the day. Yeah; 10b5-1.
2. So is messenger RNA (mRNA) safe or not?
The TL;DR is; we simply don’t know.
And that’s reason enough not to go down this alley.
With the effects having the potential to permanently change our species’ DNA in ways we can’t possibly predict in the long-term, it’s the ultimate gamble. In fact, technically you’re no longer human according to the original blueprint, because after introducing foreign DNA, you become a chimera. All for a flu shot. Worth it?
In a 2017 TED Talk, two years after joining Moderna, Chief Medical Officer Dr. Tal Zaks spoke at length about how he views mRNA vaccines and their functionality, including those he produces at Moderna. In a speech entitled ‘The disease-eradicating potential of gene editing,’ Zaks’ description of Moderna’s mRNA products as making permanent edits to human genes clashes with often touted claims that the genetic material in mRNA vaccines “degrade” over time and do not permanently alter human genetics like DNA vaccines.
At the beginning of his talk, Zaks states that Moderna and similar companies;
“…are actually hacking the software of life and that it’s changing the way we think of and treat disease.” He describes mRNA as “critical information that determines what a cell will actually do” and then states that if one could “introduce a line of code or change a line of code” in a person’s genome, that has “profound implications for everything.”Dr Tal Zaks
He then falsely claims that Moderna’s products at the time were proven to “work in people”, yet the company was never able to convince the federal government to license its mRNA vaccines for human use due to their lack of effectiveness, excluding having it’s CCP virus vaccine, mRNA-1273, fast-tracked into human trials, skipping animal trials, March 16, 2020.
Interestingly, the recommended talk on the ‘TED talks’ website that immediately follows Zak’s talk is titled; ‘Gene Editing Can Now Change an Entire Species – Forever‘, by Jennifer Kahn.
She explains how this exact technology can result in the entire eradication of a species, depending on what ‘message’ the RNA inserted into the human body has for our cells. And mRNA is a long way from being an exact science, nor do the population have any real way of knowing exactly what ‘instructions’ are being delivered to their DNA.
High stakes, wouldn’t you say?
(She goes on to state that CRISPR technology can not be used to engineer viruses. Whether the tech evolved in the 12 months after the talk was given, or she got that one ‘accidentally’ wrong is unclear.)
“…better understanding of [RNA] vaccine adverse effects is need – these can include inflammation and autoimmune reactions”The PHG Foundation at the University of Cambridge
Autoimmune reactions are when the human immune system attacks healthy elements and processes of the body, or in other words, the body goes to war with itself.
mRNA approaches seem to attract researchers with a highly mechanistic view of human beings. The CEO of Moderna, Bancel, describes mRNA approaches—which use “custom-built” strands of mRNA to “turn the body’s cells into ad hoc drug factories”—as being “like software: You can just turn the crank and get a lot of products going into development.” Likewise, the journal Nature enthuses that the approach “allows rapid refinement with almost limitless combinations of derivatives.”
It’s worth noting that the FDA was aware of vaccine technology outpacing our ability to predict adverse events as far back as 1999 in their publication “The Pink Sheet” [PDF], yet they seem to be OK with rushing through largely untested on humans mRNA in vaccines in 2020.
Infographic; ‘Engineering The Messenger‘ from Science.
It’s troubling that media coverage of biotech companies such as Pfizer, Moderna and Inovio have thus far not included critical reporting regarding the different branches of DARPA’s research that has produced the technology involved in creating these vaccines, leaving little room for public scrutiny of their safety, efficacy and their potential for unintended effects on human genetics.
This is concerning given that, over the past several weeks, efforts have been taking shape in many countries to enforce mandatory vaccinations once a vaccine becomes available. In some countries, it appears likely that the vaccine will not be made mandatory per say, but will be required for those who wish to return to any semblance of “normalcy” in terms of public gatherings, working certain jobs, leaving one’s home for longer periods of time and so on.
In this case a Certificate Of Vaccination I.D. (C.O.V.I.D?) will be required, and of course Bill Gates has just the thing – Quantum dot tattoos.
Moderna’s co-founder, MIT’s Robert Langer, is a Gates associate, whose lab developed the Gates-funded ‘Quantum Dot Tattoo’ (QDot) vaccine identification marker that is “visible using a special smartphone camera app and filter”
Another Langer-Gates partnership is a “birth control microchip” inserted to the body that releases contraceptives and can be turned on and off wirelessly.
The QDot tattoos are a story within themselves, so I’ve detailed it in a separate post, but they require an enzyme called ‘Luciferase’ to work.
Can’t make this stuff up.
Given that the stage has already been set for mandatory vaccinations that will be “distributed” throughout the U.S. by the military, and by other means globally, now is the time to vigorously raise awareness about mRNA-based vaccine’s gravely under-reported ability to “hack the software of life” in ways that could harm public health.
And to think, all this fuss when that age-old panacea, hydroxychloroquine could have put this virus behind us long ago.
*CORONAVIRUS GIVES A DANGEROUS BOOST TO DARPA’S DARKEST AGENDA. – Whitney Webb.
*The Banning of HCQ Will be the ‘Fake News’ Blunder to Rule Them All – CHI
*The Gates of Hell & ‘Luciferase’ – CHI